Microglial Activation Parallels System Degeneration in Multiple System Atrophy
نویسندگان
چکیده
منابع مشابه
Microglial activation parallels system degeneration in multiple system atrophy.
Multiple system atrophy (MSA) is a neurodegenerative disorder that predominantly affects motor-related neuroanatomic structures. The role of microglia in MSA is unknown. To address this issue, we conducted quantitative image studies on the brains from 13 cases of MSA, comprising 8 cerebellar and 5 parkinsonian variants. Microglial and glial cytoplasmic inclusion (GCI) burdens were determined wi...
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Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder. Its histopathological features include glial cytoplasmic inclusions that contain α-synuclein as the main component. Recently, multiple lines of evidence have suggested a role for lysosomes in the pathogenesis of many neurodegenerative diseases. To elucidate whether lysosomes are also implicated in the pathology of MSA, we c...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2004
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/63.1.43